אונקולוגיה והמטולוגיה
המרכז למחקר רפואי פלסנשטיין

חקר הטלומרים והאקסוזומים

המרכז למחקר רפואי פלסנשטיין

ראשי המחקר שלנו פרסומים נבחרים הצוות לכל המעבדות

חקר הטלומרים והאקסוזומים

פרסומים נבחרים

2016

  • Tumor cells derived exosomes contain hTERT mRNA and transform nonmalignant fibroblasts into telomerase positive cells.
    Gutkin A, Uziel O, Beery E, Nordenberg J, Pinchasi M, Goldvaser H, Henick S, Goldberg M, Lahav M.
    Oncotarget. 2016 Sep 13;7(37):59173-59188. doi: 10.18632/oncotarget.10384. PMID: 27385095; PMCID: PMC5312303.
    למחקר
  • BRCA1/2 mutations perturb telomere biology: characterization of structural and functional abnormalities in vitro and in vivo.
    Uziel O, Yerushalmi R, Zuriano L, Naser S, Beery E, Nordenberg J, Lubin I, Adel Y, Shepshelovich D, Yavin H, Ben Aharon I, Pery S, Rizel S, Pasmanik-Chor M, Frumkin D, Lahav M.
    Oncotarget. 2016 Jan 19;7(3):2433-54. doi: 10.18632/oncotarget.5693. PMID: 26515461; PMCID: PMC4823046.
    למחקר

2018

  • The Effect of Ethanol on Telomere Dynamics and Regulation in Human Cells.
    Harpaz T, Abumock H, Beery E, Edel Y, Lahav M, Rozovski U, Uziel O.
    Cells. 2018 Oct 15;7(10):169. doi: 10.3390/cells7100169. PMID: 30326633; PMCID: PMC6210749.
    למחקר

2019

  • STAT3-Induced Wnt5a Provides Chronic Lymphocytic Leukemia Cells with Survival Advantage.
    Rozovski U, Harris DM, Li P, Liu Z, Jain P, Ferrajoli A, Burger JA, Bose P, Thompson PA, Jain N, Wierda WG, Uziel O, Keating MJ, Estrov Z.
    J Immunol. 2019 Dec 1;203(11):3078-3085. doi: 10.4049/jimmunol.1900389. Epub 2019 Oct 23. PMID: 31645416; PMCID: PMC6864283.
    למחקר
  • Changes during Critical Illness: A Prospective, Observational Study.
    Zribi B, Uziel O, Lahav M, Mesilati Stahy R, Singer P. Telomere Length
    Genes (Basel). 2019 Sep 27;10(10):761. doi: 10.3390/genes10100761. PMID: 31569793; PMCID: PMC6826589.
    למחקר
  • The Effects of Proteasome Inhibitors on Telomerase Activity and Regulation in Multiple Myeloma Cells.
    Shalem-Cohavi N, Beery E, Nordenberg J, Rozovski U, Raanani P, Lahav M, Uziel O.
    Int J Mol Sci. 2019 May 21;20(10):2509
    למחקר

2020

  • Premature ageing following allogeneic hematopoietic stem cell transplantation.
    Uziel O, Lahav M, Shargian L, Beery E, Pasvolsky O, Rozovski U, Raanani P, Yeshurun M.
    Bone Marrow Transplant. 2020 Jul;55(7):1438-1446. doi: 10.1038/s41409-020-0839-z. Epub 2020 Feb 24. Erratum in: Bone Marrow Transplant. 2020 Jul;55(7):1519.
    למחקר

2021

  • Chronic Pain and Premature Aging - The Moderating Role of Physical Exercise.
    Lahav Y, Levy D, Ohry A, Zeilig G, Lahav M, Golander H, Guber AC, Uziel O, Defrin R.
    J Pain. 2021 Feb;22(2):209-218
    למחקר
  • Premature Aging Among Trauma Survivors-The Longitudinal Implications of Sleep Disruptions on Telomere Length and Cognitive Performance.
    Aloni R, Levin Y, Uziel O, Solomon Z.
    J Gerontol B Psychol Sci Soc Sci. 2021 Jan 18;76(2):262-272.
    למחקר

2022

  • Identification of Cancer Cells in the Human Body by Anti-Telomerase Peptide Antibody: Towards the Isolation of Circulating Tumor Cells.
    Karpov O, Lahav M, Wolach O, Raanani P, Peer D, Kaplan T, Uziel O.
    Int J Mol Sci. 2022 Oct 25;23(21):12872. doi: 10.3390/ijms232112872. PMID: 36361679; PMCID: PMC9654147.
    למחקר
  • Characterization of blood-derived exosomal hTERT mRNA as a biomarker for colon cancer and Lynch syndrome.
    Laish I, Levi Z, Mahajna H, Albshesh A, Horesh N, Katz E, Feldman D, Shinar N, Picard O, Yavzori M, Fudim E, Raanani P, Berger T, Goldvaser H, Beery E, Uziel O.
    Front Oncol. 2022 Sep 20;12:962473. doi: 10.3389/fonc.2022.962473. PMID: 36203446; PMCID: PMC9530579.
    למחקר
  • Exosomal telomerase transcripts reprogram the microRNA transcriptome profile of fibroblasts and partially contribute to CAF formation.
    Likonen D, Pinchasi M, Beery E, Sarsor Z, Signorini LF, Gervits A, Sharan R, Lahav M, Raanani P, Uziel O.
    Sci Rep. 2022 Sep 30;12(1):16415. doi: 10.1038/s41598-022-20186-8. PMID: 36180493; PMCID: PMC9525320.
    למחקר
  • Shorter Telomeres Among Individuals With Physical Disability: The Moderating Role of Perceived Stress.
    Lahav Y, Avidor S, Levy D, Ohry A, Zeilig G, Lahav M, Golander H, Guber AC, Uziel O, Defrin R.
    J Gerontol B Psychol Sci Soc Sci. 2022 Aug 11;77(8):1384-1393.
    למחקר

2023

  • Cancer cells possess different isotopic enrichment: Isotopic induced functionalizations of normal DNA mutations leading to cancer.
    Little RB, Snowton M, Uziel O.
    Heliyon. 2023 Dec 9;10(1):e23519. doi: 10.1016/j.heliyon.2023.e23519. PMID: 38170065; PMCID: PMC10758867.
    למחקר
  • Differences in Telomere Length between Adolescent Females with Anorexia Nervosa Restricting Type and Anorexia Nervosa Binge-Purge Type.
    Uziel O, Dickstein H, Beery E, Lewis Y, Loewenthal R, Uziel E, Shochat Z, Weizman A, Stein D.
    Nutrients. 2023 Jun 1;15(11):2596. doi: 10.3390/nu15112596. PMID: 37299559; PMCID: PMC10255620.
    למחקר
  • Blood-Derived Exosomal hTERT mRNA in Patients with Lung Cancer: Characterization and Correlation with Response to Therapy.
    Rotem O, Zer A, Yosef L, Beery E, Goldvaser H, Gutkin A, Levin R, Dudnik E, Berger T, Feinmesser M, Levy-Barda A, Lahav M, Raanani P, Uziel O.
    Biomedicines. 2023 Jun 16;11(6):1730. doi: 10.3390/biomedicines11061730. PMID: 37371825; PMCID: PMC10295971.
    למחקר

2024

  • Chronic Lymphocytic Leukemia (CLL)-Derived Extracellular Vesicles Educate Endothelial Cells to Become IL-6-Producing, CLL-Supportive Cells.
    ChronUziel O, Lipshtein L, Sarsor Z, Beery E, Bogen S, Lahav M, Regev A, Kliminski V, Sharan R, Gervits A, Signorini LF, Shimony S, Raanani P, Rozovski U.
    Biomedicines. 2024 Jun 21;12(7):1381.
    למחקר
  • Is serum-derived exosomal hTERT transcript a marker of oncogenic activity in primary brain tumors? An exploratory study.
    Uziel O, Kanner AA, Beery E, Lev S, Lahav M, Horn-Fichman S, Nof SH, Laviv Y, Yust-Katz S, Amiel A, Shkara RA, Siddeeq M, Levy-Barda A, Raanani P, Sela Y, Cohen Z, Siegal T.
    Cancer Med. 2024 Jan;13(1):e6784.
    למחקר

ראש/ת המעבדה

פרופ' פיה רענני

מנהל/ת המעבדה

ד"ר איזבל פטיט

צוות מחקר

  • טכנאית: זינאב סרסור (M.Sc.)
  • פרופ' אורית עוזיאל

איש קשר

  • פרופ' אורית עוזיאל

יצירת קשר

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