גסטרואנטרולוגיה ומחלות כבד
המרכז למחקר רפואי פלסנשטיין

חקר מחלות מעי דלקתיות בילדים

המרכז למחקר רפואי פלסנשטיין

ראשי המחקר שלנו פרסומים נבחרים הצוות לכל המעבדות

חקר מחלות מעי דלקתיות בילדים

פרסומים נבחרים

2009

  • Living-Related Donor Liver transplantation for Children with Fulminant Hepatic Failure in Israel.
    Shouval DS, Mor E, Avitzur Y, Shamir R, Bar-Nathan N, Steinberg R, Schoenfeld T, Ben-Ari Z, Shapiro R.
    J Pediatr Gastroenterol Nutr. 2009 Apr;48(4):451-5.
    למחקר
  • Serotype Coverage of Invasive and Mucosal Pneumococcal Disease in Israeli Children Younger than 3 Years by Various Pneumococcal Conjugate Vaccines.
    Shouval DS, Greenberg D, Givon-Lavi N, Porat N, Dagan R.
    Pediatr Infect Dis J. 2009 Apr;28(4):277-82.
    למחקר

2014

  • Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans.
    Shouval DS, Ouahed J, Biswas A, Goettel JA, Klein C, Horwitz BH, Snapper SB.
    Adv Immunol. 2014;122:177-210.
    למחקר
  • Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function.
    Shouval DS, Biswas A, Goettel JA, McCann K, Conaway E, Redhu NS, Mascanfroni ID, Al Adham Z, Lavoie S, Ibourk M, Nguyen DD, Samsom JN, Escher JC, Somech R, Weiss B, Beier R, Conklin LS, Ebens CL, Santos FG, Ferreria AR, Sherlock M, Bhan WK, Muller W, Mora JR, Quintana FJ, Klein C, Muise AM, Horwitz BH, Snapper SB.
    Immunity. 2014 May 15;40(5):706-19.
    למחקר

2015

  • Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.
    Goettel JA, Biswas S, Lexmond WS, Yeste A, Passerini L, Patel B, Yang S, Sun J, Ouahed J, Shouval DS, McCann KJ, Horwitz BH, Mathis D, Milford EL, Notarangelo LD, Roncarolo MG, Fiebiger E, Marasco WA, Bacchetta R, Quintana FJ, Pai SY, Muise AM, Snapper SB.
    Blood. 2015 Jun 18;125(25):3886-95.
    למחקר

2016

  • Large B-cell lymphoma in an adolescent patient with IL-10 receptor deficiency and history of infantile inflammatory bowel disease.
    Shouval DS, Ebens CL, Murchie R, McCann K, Rabah R, Klein C, Muise AM, Snapper SB.
    J Pediatr Gastroenterol Nutr. 2016 Jul;63(1):e15-7.
    למחקר
  • Novel exonic mutation inducing aberrant splicing in the IL10RA gene and resulting in infantile-onset inflammatory bowel disease.
    Yanagai T, Mizuochi T, Takaki Y, Keisuke E, Mitsuyama K, Ishimura M, Takada H, Shouval DS, Griffith AE, Snapper SB, Yamashita Y, Yamamoto K.
    BMC Gastroenterology, 2016 Jan 28;16:10.
    למחקר
  • Variants in TRIM22 that Affect NOD2 Signaling Are Associated With Very Early Onset Inflammatory Bowel Disease.
    Li Q, Lee CH, Peters LA, Mastropaolo LA, Thoeni C, Elkadari A, Schwerd T, Zhu J, Zhang B, Zhap Y, Hao K, Dinarzo A, Hoffman G, Kidd BA, Murchie R, Al Adham Z, Guo C, Kotlarz D, Cutz E, Walters TD, Shouval DS, Curran M, Dobrin R, Brodmerkel C, Snapper SB, Klein C, Brumell JH, Hu M, Nagan R, Snanter-Nanan B, Wong M, Le Diset F, Haddad E, Roifman CM, Deslandres C, Griffith AM, Gaskin KJ, Uhlig HH, Schadt EE, Muise AM.
    Gastroenterolgy, 2016 May; 150 (5):1196-207.
    למחקר
  • IL-10 induces a STAT3dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes.
    Poholek AC, Jankovic D, Villarino AV, Petermann F, Hettinga A, Shouval DS, Snapper SB, Kaech SM, Brooks SR, Vahedi G, Sher A, Kanno Y, O'Shea JJ.
    Sci Immunol. 2016 Oct;1(5).
    למחקר
  • AHR activation is protective against colitis driven by T cells in humanized mice.
    Goettel JA, Gandhi R, Yeste A, Sambanthamoorthy S, Patel B, Shouval DS, Weiner HL, Snapper SB and Quintana FJ.
    Cell Rep. 2016 Oct 25;17(5):1318-1329.
    למחקר
  • Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Inerleukin 10 Receptor Deficiency.
    Shouval DS*, Biswas A*, Kang YH, Griffith AE, Konnikova L, Mascanfroni, Redhu N, Frei SM, Field M, Doty AL, Goldsmith JD, Bhan A, Loizides A, Weiss B, Tadahiro Y, Quintana FJ, Muise AM, Klein C, Horwitz BH, Glover SC, Bousvaros A, Snapper SB.
    Gastroenterology. 2016 Dec;151(6):1100-1104. *equal contribution.
    למחקר

2017

  • Increased Mucosal IL-22 Production of an IL-10RA Mutation Patient Following Anakinra Treatment Suggests Further Mechanism for Mucosal Healing. J Clin Immunol. 2017 Feb;37(2):104-107.
    Li J, Shouval DS, Doty AL, Snapper SB, Glover SC.
    למחקר
  • Anti-inflammatory Effect of IL-10 Mediated by Metabolic Reprogramming of Macrophages.
    WKE IP, Hoshimi N, Shouval DS, Snapper S, Medzhitov R.
    Science, 2017 May 5;356(6337):513519.
    למחקר
  • Vedolizumab in pediatric inflammatory bowel disease: a retrospective multi-center experience from the Paediatric IBD Porto group of ESPGHAN.
    Ledder O, Assa A, Levine A, Escher JC, Ridder L, Ruemmele R, Shah N, Shaoul R, Wolters VM, Rodrigues A, Uhlig HH, Posovsky C, Kolho KL, Jakobsen C, Cohen S, Shouval DS, Friedman M, Turner D.
    J Crohns Colitis. 2017 Oct 1;11(10):1230-1237
    למחקר
  • Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor.
    Redhu NS, Bakthavatchalu V, Conaway EA, Shouval DS, Tsou A, Goettel JA, Biswas A, Wang C, Field M, Muller W, Bleich A, Li N, Gerber GK, Bry L, Fox JG, Snapper SB, Horwitz BH.
    Elife 2017 July 5;6. Pili: e27652.
    למחקר
  • The Role of Environmental Factors in the Pathogenesis of Inflammatory Bowel Diseases: A Review.
    Shouval DS, Rufo PA.
    JAMA Pediatr. 2017 Oct 1;171(10):999-1005.
    למחקר
  • Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD. Inflamm Bowel
    Shouval DS*, Konnikova L*, Griffith AE, Wall SM, Biswas A, Werner L, Nunberg M, Kammermeier J, Goettel JA, Anand R, Chen H, Weiss B, Li J, Loizides A, Yerushalmi B, Yanagi T, Beier R, Conklin LS, Ebens CL, Santos FGMS, Sherlock M, Goldsmith JD, Kotlarz D, Glover SC, Shah N, Bousvaros A, Uhlig HH, Muise AM, Klein C, Snapper SB.
    Dis. 2017 Nov;23(11):1950-1961. *equal contribution.
    למחקר

2018

  • WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis;
    Biswas A, Shouval DS, Griffith A, Goettel JA, Field M, Kang YH, Konnikova L, Janssen E, Redhu NS, Thrasher AJ, Chatila T, Kuchroo VK, Geha RF, Notarangelo LD, Pai SY, Horwitz BH, Snapper SB.
    Nat Commun. 2018 May 3;9(1):1779.
    למחקר
  • Impaired IL10 Receptor Mediated Suppression in Monocyte from Patients with Crohn's Disease
    Nunberg MY, Werner L, Kopylov U, Haberman Y, Lahad A, Weiss B, Shouval DS.
    J Pediatr Gastroenterol Nutr. 2018 May;66(5):779-784.
    למחקר
  • Genetic and Structural Analysis of a SKIV2L Mutation Causing Tricho-hepato-enteric Syndrome.
    Vardi I, Barel O, Sperber M, Schvimer M, Nunberg M, Field M, Ouahed J, Marek-Yagel D, Werner L, Haberman Y, Lahad A, Anikster Y, Rechavi G, Barshack I, McElwee JJ, Maranville J, Somech R, Snapper SB, Weiss B, Shouval DS.
    Dig Dis Sci. 2018 May;63(5):1192-1199.
    למחקר
  • The Treatment of Inflammatory Bowel Disease in Patients with Selected Primary Immunodeficiencies.
    Shouval DS, Kowalik M, Snapper SB.
    J Clin Immunol. 2018 Jul;38(5):579-588.
    למחקר
  • Molecular Comparison of Adult and Pediatric Ulcerative Colitis Indicates Broad Similarity of Molecular Pathways in Disease Tissue.
    Li K, Strauss R, Ouahed J, Chan D, Telesco SE, Shouval DS, Canavan JB, Brodmerkel C, Snapper SB, Friedman JR.
    J Pediatr Gastroenter Nutr. 2018 Jul;67(1):45-52.
    למחקר
  • Combined Gastric and Pancreatic Tissue Inside a Meckel's Diverticulum.
    Shemer A, Talmi L, Shouval DS, Har-Zahav G, Somech R.
    Isr Med Assoc J 2018 Jul;20(7):461-462.
    למחקר
  • Association Between Infliximab Drug and Antibody Levels and Therapy Outcome in Pediatric Inflammatory Bowel Diseases.
    Ungar B, Glidai Y, Yavzori M, Picard O, Fudim E, Lahad A, Haberman Y, Shouval DS, Weintraub I, Eliakim R, Ben-Horin S, Weiss B.
    J Pediatr Gastroenterol Nutr. 2018 Oct;67(4):507-512.
    למחקר
  • Intestinal epithelial cells and T cells differentially recognize and respond to Candida albicans yeast and hypha.
    Schirbel A, Shouval DS, Hebecker B, Hube B, Sturm A, Werner L.
    Eur J Immunol. 2018 Nov;48(11):1826-1837.
    למחקר
  • Mucosal gene expression in pediatric and adult patients with ulcerative colitis permits modeling of ideal biopsy collection strategy for transcriptomic analysis.
    Ouahed J, Gordon W, Canavan JBC, Zhou H, Du S, Von Schack D, Phillips K, Wang L, Augustin Dunn III W, Field M, Friel S, Griffith AE, Evans S, Tollefson S, Carellas M, Cao M, Merker A, Bousvaros A, Shouval DS, Hung K, Lepsy C, AfzeliusL, Korzenik JR, Snapper SB.
    Inflamm Bowel Dis. 2018 Nov 29;24(12):2565-2578.
    למחקר

2019

  • Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency.
    Lehle AS, Farin HF, Marquardt B, Michels BE, Magg T, Li Y, Liu Y, Ghalandary M, Lammens K, Hollizeck S, Rohlfs M, Hauck F, Conca R, Walz C, Weiss B, Lev A, Simon AJ, Groß O, Gaidt MM, Hornung V, Clevers H, Yazbeck N, Hanna-Wakim R, Shouval DS, Warner N, Somech R, Muise AM, Snapper SB, Bufler P, Koletzko S, Klein C, Kotlarz D.
    Gastroenterology. 2019 Jan;156(1):275-278.
    למחקר
  • Altered T cell receptor beta repertoire patterns in pediatric ulcerative colitis.
    Werner L, Nunberg MY, Rechavi E, Lev A, Braun T, Haberman Y, Lahad A, Shteyer E, Schvimer M, Somech R, Weiss B, Lee YN, Shouval DS.
    Clin Exp Immunol. 2019 Apr;196(1):1-11.
    למחקר
  • A Unique Presentation of Infantile-Onset Colitis and Eosinophilic Disease without Recurrent Infections Resulting from a Novel Homozygous CARMIL2 Variant. J Clin Immunol. 2019 May;39(4):430-439. *=equal senior and corresponding authors. Shouval DS, Ben-Horin S. Biomarker predictors of non-response to TNFα antagonists-the quest continues. Aliment Pharmacol Ther. 2019;49(8):1089-1090.
    Kurolap A, Eshach Adiv O, Konnikova L, Werner L, Gonzaga-Jauregui C, Steinberg M, Mitsialis V, Mory A, Nunberg MY, Wall S, Shaoul R, Overton JD; Regeneron Genetics Center, Shuldiner AR, Zohar Y, Paperna T, Snapper SB, Shouval DS*, Baris Feldman H*.
    למחקר
  • Cerebral and portal vein thrombosis, macrocephaly and atypical absence seizures in Glycosylphosphatidyl inositol deficiency due to a PIGM promoter mutation.
    Pode-Shakked B, Heimer G, Vilboux T, Marek-Yagel D, Ben-Zeev B, Davidsh M, Ferreirai CR, Philosoph AM, Veber A, Pode-Shakked N, Kenet G, Soudack M, Hoffmann C, Vernitskyn H, Safanievn M, Lodzkio M, Lahad A, Shouval DS, Levinkopf D, Weiss B, Barg AA, Daka A, Amariglio N, Malicdane MCV, Gahl WA, Anikster Y.
    Mol Genet Metab. 2019;128(1-2):151-161.
    למחקר
  • Priming and Maturation of the Human Fetal Mucosal Immunity Occurs Early in Fetal Development.
    Stras S, Warner L, Toothaker J, Oldham A, Olaloye O, Lee YN, Rechavi E, Shouval DS*, Konnikova L*.
    Dev Cell. 2019 Nov 4;51(3):357-373.e5. *=equal senior and corresponding authors.
    למחקר
  • Humanized mouse models of genetic immune disorders and hematological malignancies.
    Tyagi RK, Li J, Jacobse J, Snapper SB, Shouval DS, Goettel JA.
    Biochem Pharmacol. 2019 Oct 18:113671.
    למחקר
  • Position paper: Anti-TNFα drug and anti-drug monitoring in pediatric patients with inflammatory bowel disease.
    Shouval DS, Turner D, Assa A.
    Harefuah. 2019 Nov;158(11):752-754. Hebrew.
    למחקר
  • Defining the Celiac Disease Transcriptome using Clinical Pathology Specimens Reveals Biologic Pathways and Supports Diagnosis.
    Loberman-Nachum N, Sosnovski K, Di Segni A, Efroni G, Braun T, BenShoshan M, Anafi L, Avivi C, Barshack I, Shouval DS, Denson LA, Amir A, Unger R, Weiss B, Haberman Y.
    Sci Rep. 2019 Nov 7;9(1):16163.
    למחקר
  • Long-term Outcomes of Paediatric Patients Admitted with Acute Severe Colitis - A Multicenter Study from the Paediatric IBD Porto Group of ESPGHAN.
    Krauthammer A, Tzivinikos C, Assa A, Miele E, Strisciuglio C, Urlep D, Serban ED, Singh A, Winter HS, Russell RK, Hojsak I, Malham M, Navas-López VM, Croft NM, Lee HM, Ledder O, Shamasneh I, Hussey S, Huynh H, Wine E, Shah N, Sladek M, de Meij TG, Romano C, Dipasquale V, Lionetti P, Afzal NA, Aloi M, Lee K, Martín-de-Carpi J, Yerushalmy-Feler A, Subramanian S, Weiss B, Shouval DS.
    J Crohns Colitis. 2019 Dec 10;13(12):1518-1526.
    למחקר

2020

  • Alterations in T and B Cell Receptor Repertoires Patterns in Patients With IL10 Signaling Defects and History of Infantile-Onset IBD.
    Werner L, Lee YN, Rechavi E, Lev A, Yerushalmi B, Ling G, Shah N, Uhlig HH, Weiss B, Somech R, Snapper SB, Shouval DS.
    Front Immunol. 2020 Feb 6;11:109.
    למחקר
  • Knowledge of disease and self-management of adolescents with inflammatory bowel diseases.
    Krauthammer A, Harel T, Zevit N, Shouval DS, Shamir R, Weiss B.
    Acta Paediatr. 2020 Feb 5.
    למחקר
  • Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies. .
    Ouahed J, Spencer E, Kotlarz D, Shouval DS, Kowalik M, Peng K, Field M, Grushkin-Lerner L, Pai SY, Bousvaros A, Cho J, Argmann C, Schadt E, Mcgovern DPB, Mokry M, Nieuwenhuis E, Clevers H, Powrie F, Uhlig H, Klein C, Muise A, Dubinsky M, Snapper SB.
    Inflamm Bowel Dis. 2020 May 12;26(6):820-842
    למחקר
  • An RTEL1 Mutation Links to Infantile-onset Ulcerative Colitis and Severe Immunodeficiency.
    Ziv A, Werner L, Konnikova L, Awad A, Jeske T, Hastreiter M, Mitsialis V, Stauber T, Wall S, Kotlarz D, Klein C, Snapper SB, Tzfati Y, Weiss B, Somech R, Shouval DS.
    Journal of Clinical Immunology, 2020 Oct;40(7):1010-1019.
    למחקר
  • Infliximab in young paediatric IBD patients: it is all about the dosing Eur
    Jongsma MME, Winter DA, Huynh HQ, Norsa L, Hussey S, Kolho KL, Bronsky J, Assa A, Cohen S, Lev-Tzion R, Van Biervliet S, Rizopoulos D, de Meij TGJ, Shouval DS, Wine E, Wolters VM, Martinez-Vinson C, de Ridder L; Paediatric IBD Porto Group of ESPGHAN.
    J Pediatr. 2020 Aug 19.
    למחקר
  • Antibodies Against Glycoprotein 2 Are Specific Biomarkers for Pediatric Crohn's Disease.
    Shpoliansky M, Roggenbuck D, Pinsker M, Salamon N, Weiss B, Shouval DS, Werner L.
    Dig Dis Sci. 2020 Sep 4.
    למחקר
  • It’s Never Too Late to Make a Diagnosis.
    Vard I, Chermesh I, Werner L, Barel O, Freund T, McCourt C, Fisher Y, Pinsker M, Javasky E, Weiss B, Rechavi G, Hagin D, Snapper SB, Somech R, Konnikova L, Shouval DS. Monogenic IBD:
    Front Immunol. 2020 Sep 4;11:1775.
    למחקר
  • Gastrointestinal Hemorrhage: A Manifestation of the Telomere Biology Disorders.
    Himes RW, Chiou EH, Queliza K, Shouval DS, Somech R, Agarwal S, Jajoo K, Ziegler DS, Kratz CP, Huang J, Lucas TL, Myers KC, Nelson AS, DiNardo CD, Alter BP, Giri N, Khincha PP, McReynolds LJ, Dufour C, Pierri F, Goldman FD, Sherif Y, Savage SA, Miloh T, Bertuch AA.
    J Pediatr. 2020 Sep 21;S0022-3476(20)31171-9.
    למחקר
  • Therapeutic Drug Monitoring Guided High Dose Infliximab for Infantile-Onset Inflammatory Bowel Disease: A Case Series.
    Assa A, Dorfman L, Shouval DS, Shamir R, Cohen S.
    J Pediatr Gastroenterol Nutr. 2020 Oct;71(4):516-520.
    למחקר
  • Circulating α4β7+ Memory T Cells in Pediatric IBD Patients Express a Polyclonal T Cell Receptor Repertoire.
    Gamliel A, Werner L, Pinsker M, Salamon N, Weiss B, Shouval DS.
    Clin Exp Gastroenterol. 2020 Oct 2;13:439-447.
    למחקר
  • Trabecular Bone Score in Children and Adolescents with Inflammatory Bowel Diseases.
    Levy-Shraga Y, Megnazi O, Modan-Moses D, Tripto-Shkolnik L, Gruber N, Haberman Y, Shouval DS, Weiss B.
    J Clin Densitom. 2020:S1094-6950(20)30134-7.
    למחקר
  • Evaluation of very early-onset inflammatory bowel disease.
    de Mesquita MB, Shouval DS.
    Curr Opin Gastroenterol. 2020 Nov;36(6):464-469.
    למחקר
  • Enhanced Collagen Deposition in the Duodenum of Patients with Hyaline Fibromatosis Syndrome and Protein Losing Enteropathy.
    van Rijn JM, Werner L, Aydemir Y, Spronck JMA, Pode-Shakked B, van Hoesel M, Shimshoni E, Polak-Charcon S, Talmi L, Eren M, Weiss B, H J Houwen R, Barshack I, Somech R, Nieuwenhuis EES, Sagi I, Raas-Rothschild A, Middendorp S*, Shouval DS*.
    Int J Mol Sci. 2020 Nov 2;21(21):E8200. *Equal corresponding authors.
    למחקר
  • In utero human intestine harbors unique metabolome, including bacterial metabolites.
    Li Y, Toothaker JM, Ben-Simon S, Ozeri L, Schweitzer R, McCourt BT, McCourt CC, Werner L, Snapper SB, Shouval DS, Khatib S, Koren O, Agnihorti S, Tseng G, Konnikova L.
    JCI Insight. 2020;5(21):e138751.
    למחקר
  • Distinct extracellular-matrix remodeling events precede symptoms of inflammation.
    Shimshoni E, Adir I, Afik R, Solomonov I, Shenoy A, Adler M, Puricelli L, Ghini L, Mouhadeb O, Gluck N, Fishman S, Werner L, Shouval DS, Varol C, Podestà A, Turano P, Geiger T, Milani P, Luchinat C, Alon U, Sagi I.
    Matrix Biol. 2020 Nov 25:S0945-053X(20)30103-7.
    למחקר
  • Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer.
    Levi-Galibov O, Lavon H, Wassermann-Dozorets R, Pevsner-Fischer M, Mayer S, Wershof E, Stein Y, Brown L, Zhang W, Friedman G, Nevo R, Golani O, Katz L, Yaeger R, Laish I, Porco J, Sahai E, Shouval DS, Kelsen D and Scherz-Shouval R.
    Nat Commun. 2020 Dec 7;11(1):6245.
    למחקר
  • Approach to very early onset inflammatory bowel disease.
    Ouahed J, Spencer E, Kotlarz D, Shouval DS, Kowalik M, Peng K, Field M, Grushkin-Lerner L, Pai SY, Bousvaros A, Cho J, Argmann C, Schadt E, Mcgovern DPB, Mokry M, Nieuwenhuis E, Clevers H, Powrie F, Uhlig H, Klein C, Muise A, Dubinsky M, Snapper SB.
    Harefua. 2020 Mar;159(3):206-211. Hebrew.
    למחקר

2021

  • Mucosal IL-10 and IL-10 receptor expression patterns in paediatric patients with ulcerative colitis.
    Wittmann-Dayagi T, Werner L, Pinkser M, Salamon N, Barschak I, Weiss B, Shouval DS.
    Int J Exp Pathol 2021 Feb; 102(1):4-10.
    למחקר
  • T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing.
    Werner L, Dor C, Salamon N, Nagar M, Shouval DS.
    J Vis Exp. 2021 Jan 12;(167).
    למחקר
  • Predictive Prenatal Diagnosis for Infantile-onset Inflammatory Bowel Disease Because of Interleukin-10 Signalling Defects.
    Ye Z, Hu W, Wu B, Zhang Y, Lei C, Williams I, Shouval DS, Kanegane H, Kim KM, de Ridder L, Shah N, Ling G, Yerushalmi B, Kotlarz D, Snapper S, Horn R, Klein C, Muise AM, Huang Y, Uhlig HH.
    J Pediatr Gastroenterol Nutr. 2021 Feb 1;72(2):276-281.
    למחקר
  • Clinical Genomics for the diagnosis of monogenic forms of inflammatory bowel disease:A Position Paper from The Paediatric IBD Porto Group of ESPGHAN. .
    Uhlig HH, Charbit-Henrion C, Kotlarz D, Shouval DS, Schwerds T, Stisciuglio C, de Ridder L, van Limbergen J, Macchi M, Snapper SB, Ruemmele FM, Wilson DC, Travis SPL, Griffith AM, Turner D, Klein C, Muise AM, Russell RK.
    J Pediatr Gastroenterol Nutr. 2021 Mar 1;72(3):456-473
    למחקר

ראש/ת המעבדה

פרופ' דרור שובל, M.D, MMSc

מנהל/ת המעבדה

ד"ר לירן ברעם

יצירת קשר

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